Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | GBA1 | P04062 | 7/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826737 | 0.93 | RAB9A (0.56) | GRM5RAB9ANPC1GBA1TP53 | |
| SCHEMBL2833180 | 0.91 | RAB9A (0.54) | GRM5RAB9ANPC1GBA1TP53 | |
| SCHEMBL2830797 | 0.87 | RAB9A (0.51) | GRM5RAB9ANPC1GBA1TP53 | |
| SCHEMBL2824990 | 0.87 | RAB9A (0.51) | GRM5RAB9ANPC1GBA1TP53 | |
| SCHEMBL2830006 | 0.85 | RAB9A (0.44) | GRM5RAB9ANPC1GBA1TP53 | |
| SCHEMBL2833195 | 0.85 | RAB9A (0.43) | GRM5RAB9ANPC1GBA1TP53 | |
| SCHEMBL2826324 | 0.84 | NPC1 (0.58) | GRM5RAB9ANPC1GBA1MEN1 | |
| SCHEMBL2830129 | 0.84 | CYP1A2 (0.44) | GRM5RAB9ANPC1GBA1TP53 | |
| SCHEMBL2829836 | 0.83 | RAB9A (0.42) | GRM5RAB9ANPC1GBA1TP53 | |
| SCHEMBL2825843 | 0.82 | GRM5 (0.58) | GRM5RAB9ANPC1GBA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |