Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831219 | 0.91 | NPC1 (0.37) | GRM5NPC1RAB9AMAPK1NTRK1 | |
| SCHEMBL2826482 | 0.89 | NPC1 (0.40) | GRM5NPC1RAB9AMAPK1KDM4E | |
| SCHEMBL2827806 | 0.88 | GRM5 (0.44) | GRM5NPC1RAB9AMAPK1NTRK1 | |
| SCHEMBL2831104 | 0.87 | GRM5 (0.37) | GRM5NPC1RAB9AKDM4ELMNA | |
| SCHEMBL2827684 | 0.85 | GRM5 (0.48) | GRM5NPC1RAB9ANOTUMJAK2 | |
| SCHEMBL2828252 | 0.84 | CSNK2A1 (0.35) | NPC1RAB9AMAPK1NTRK1RAF1 | |
| SCHEMBL2832204 | 0.84 | GRM5 (0.56) | GRM5JAK2 | |
| SCHEMBL2830056 | 0.83 | GRM5 (0.39) | GRM5NPC1RAB9AMAPK1PIK3CA | |
| SCHEMBL2828128 | 0.82 | NPC1 (0.38) | GRM5NPC1RAB9ANTRK1KDM4E | |
| SCHEMBL17685481 | 0.82 | GCK (0.36) | NPC1RAB9AMAPK1NTRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |