Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831219 | 0.91 | NPC1 (0.37) | RAF1NPC1RAB9ANTRK1MAPK1 | |
| SCHEMBL2830183 | 0.88 | NPC1 (0.40) | NPC1RAB9A | |
| SCHEMBL2830074 | 0.85 | CSNK2A1 (0.38) | CSNK2A1 | |
| SCHEMBL2830071 | 0.84 | GRM5 (0.39) | RAF1NPC1RAB9ANTRK1MAPK1 | |
| SCHEMBL2826367 | 0.81 | GRM5 (0.44) | CSNK2A1IDH1 | |
| SCHEMBL2828128 | 0.79 | NPC1 (0.38) | RAF1NPC1RAB9ANTRK1 | |
| SCHEMBL2827806 | 0.79 | GRM5 (0.44) | RAF1NPC1RAB9ANTRK1MAPK1 | |
| SCHEMBL2828458 | 0.78 | ACSS2 (0.36) | RAF1NPC1RAB9A | |
| SCHEMBL2825870 | 0.78 | NPC1 (0.39) | NPC1RAB9AMAPK1 | |
| SCHEMBL2826482 | 0.77 | NPC1 (0.40) | RAF1NPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |