Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.48 |
| ▸ | NAMPT | P43490 | 5/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SIGLEC9 | Q9Y336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827806 | 0.89 | GRM5 (0.44) | GRM5NPC1RAB9ANOTUM | |
| SCHEMBL2826935 | 0.87 | GRM5 (0.46) | GRM5NAMPTTSHR | |
| SCHEMBL2826482 | 0.85 | NPC1 (0.40) | GRM5NPC1RAB9A | |
| SCHEMBL2830071 | 0.85 | GRM5 (0.39) | GRM5JAK2PIK3CANPC1RAB9A | |
| SCHEMBL2826273 | 0.83 | GRM5 (0.56) | GRM5NAMPTJAK2JAK3PIK3CG | |
| SCHEMBL5199705 | 0.83 | GRM5 (0.70) | GRM5NAMPTTSHRNPC1RAB9A | |
| SCHEMBL2824785 | 0.83 | GRM5 (0.70) | GRM5JAK2JAK3NPC1RAB9A | |
| SCHEMBL2827389 | 0.83 | GRM5 (0.51) | GRM5NAMPTJAK2JAK3PIK3CG | |
| SCHEMBL2826008 | 0.82 | GRM5 (0.57) | GRM5JAK2JAK3PIK3CGPIK3CA | |
| SCHEMBL2831219 | 0.82 | NPC1 (0.37) | GRM5NPC1RAB9ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |