SCHEMBL28301021

SCHEMBL28301021

COc1ccc(-c2ccccc2-n2nc(CO)cc2-c2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CA1 P00915 7/20 0.55
CA2 P00918 7/20 0.55
CA9 Q16790 7/20 0.55
PTGS2 P35354 1/20 0.48
RPA1 P27694 1/20 0.47
CCKAR P32238 5/20 0.47
RAB9A P51151 1/20 0.46
SLC16A3 O15427 4/20 0.45
SLC16A1 P53985 3/20 0.45
FABP3 P05413 1/20 0.44
FABP4 P15090 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28300981 0.89 CCKAR (0.45) CA1CA2CA9RPA1CCKAR
SCHEMBL28301083 0.89 CA1 (0.46) CA1CA2CA9PTGS2RPA1
SCHEMBL28299743 0.84 RAB9A (0.53) PTGS2RPA1RAB9A
SCHEMBL28299729 0.82 NPC1 (0.46) PTGS2RPA1RAB9AFABP3FABP4
SCHEMBL28873761 0.81 NPSR1 (0.44) RPA1RAB9ASLC16A3SLC16A1FABP3
SCHEMBL8689248 0.81 CA9 (0.67) CA1CA2CA9PTGS2
SCHEMBL9349960 0.80 CA1 (0.77) CA1CA2CA9PTGS2RPA1
SCHEMBL28847493 0.80 GAA (0.40) CA1CA2CA9PTGS2RPA1
SCHEMBL28301248 0.78 GAA (0.49) RAB9A
SCHEMBL31130454 0.77 SLC16A3 (0.68) CA1CA2CA9SLC16A3SLC16A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109890822-B Inhibitors of cellular metabolic processes 安吉奥斯医药品有限公司 2022-08-30 CN disclosed
CN-109890822-A INHIBITORS OF CELLULAR METABOLIC PROCESSES 安吉奥斯医药品有限公司 2019-06-14 CN disclosed