Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NNMT | P40261 | 5/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15095256 | 0.77 | SIRT3 (0.43) | TSHRNNMTSIRT3TDP1SIRT6 | |
| SCHEMBL1004137 | 0.68 | KDM4E (0.50) | TSHRTDP1KDM4EALDH1A1MAPT | |
| SCHEMBL29804459 | 0.67 | SIRT3 (0.55) | TSHRNNMTSIRT3TDP1KDM4E | |
| SCHEMBL6075761 | 0.64 | KDM4E (0.41) | TSHRKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL27377658 | 0.64 | NNMT (0.36) | TSHRNNMTSIRT3TDP1KDM4E | |
| Methane SCHEMBL27687947 | 0.61 | ASPH (0.41) | SIRT3TDP1MAP4K4CDK5 | |
| SCHEMBL25255537 | 0.61 | PLAU (0.37) | SIRT6KDM4EALDH1A1CHEK1AURKA | |
| SCHEMBL17442725 | 0.60 | KDM4C (0.53) | TDP1KDM4EALDH1A1MAPT | |
| SCHEMBL9002466 | 0.60 | SIRT3 (0.61) | SIRT3TDP1SIRT6KDM4EALDH1A1 | |
| SCHEMBL5204576 | 0.60 | TSHR (0.44) | TSHRNNMTSIRT3TDP1SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109863139-A | Muscarinic acetylcholine receptor M4Positive allosteric modulators of | 范德比尔特大学 | 2019-06-07 | — | — | CN | disclosed |