Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30219527 | 0.81 | MAPKAPK2 (0.53) | MAPKAPK2 | |
| SCHEMBL28986210 | 0.81 | MAPKAPK2 (0.53) | MAPKAPK2 | |
| SCHEMBL28303127 | 0.76 | MKNK2 (0.60) | MKNK2MKNK1IRAK4MAPKAPK2RPS6KA5 | |
| SCHEMBL28303123 | 0.74 | MKNK2 (0.58) | MKNK2MKNK1IRAK4 | |
| SCHEMBL18789209 | 0.71 | MKNK2 (1.00) | MKNK2MKNK1 | |
| SCHEMBL30099082 | 0.70 | MKNK2 (0.59) | MKNK2MKNK1EGFRIRAK4 | |
| SCHEMBL8801410 | 0.70 | MKNK2 (0.59) | MKNK2MKNK1EGFRIRAK4 | |
| SCHEMBL23412407 | 0.69 | MKNK2 (0.62) | MKNK2MKNK1MAPKAPK2 | |
| SCHEMBL30093014 | 0.69 | MKNK2 (0.62) | MKNK2MKNK1MAPKAPK2 | |
| SCHEMBL23413110 | 0.69 | MKNK2 (0.58) | MKNK2MKNK1EGFRMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810110-A | A kind of compound with 2- aminopyrimidine structure, preparation method and use | 中国科学院上海药物研究所 | 2019-05-28 | — | — | CN | disclosed |