Niacin

Niacin

SCHEMBL28302152

CCCC(C(=O)O)C(=O)O.O=C(O)c1cccnc1

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.66
APP P05067 1/20 0.66
GAA P10253 1/20 0.66
HCAR3 P49019 1/20 0.66
HCAR2 Q8TDS4 1/20 0.66
L3MBTL1 Q9Y468 1/20 0.49
PLOD2 O00469 1/20 0.49
HTT P42858 1/20 0.48
TBXAS1 P24557 2/20 0.47
LMNA P02545 3/20 0.47
HDAC3 O15379 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC2 Q92769 1/20 0.47
KMO O15229 1/20 0.46
F7 P08709 1/20 0.46
F3 P13726 1/20 0.46
SARM1 Q6SZW1 1/20 0.46
SIRT2 Q8IXJ6 1/20 0.46
SIRT6 Q8N6T7 1/20 0.46
SIRT1 Q96EB6 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Niacin SCHEMBL11441069 0.85 ALDH1A1 (0.91) ALDH1A1APPGAAHCAR3HCAR2
Niacin SCHEMBL8168699 0.83 ALDH1A1 (0.81) ALDH1A1APPGAAHCAR3HCAR2
Niacin SCHEMBL28863183 0.82 ALDH1A1 (0.78) ALDH1A1APPGAAHCAR3HCAR2
Niacin SCHEMBL31228985 0.82 ALDH1A1 (0.78) ALDH1A1APPGAAHCAR3HCAR2
Niacin SCHEMBL27753119 0.82 ALDH1A1 (0.78) ALDH1A1APPGAAHCAR3HCAR2
Niacin SCHEMBL28017524 0.81 ALDH1A1 (0.91) ALDH1A1APPGAAHCAR3HCAR2
Niacin SCHEMBL27793379 0.81 ALDH1A1 (0.91) ALDH1A1APPGAAHCAR3HCAR2
Niacin SCHEMBL1433 0.81
Niacin SCHEMBL30844065 0.81
Niacin SCHEMBL29349574 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109796397-A A kind of preparation method of 3- acetylpyridine 浙江理工大学 2019-05-24 CN claimed
CN-109796397-A A kind of preparation method of 3- acetylpyridine 浙江理工大学 2019-05-24 CN disclosed
CN-109796397-A A kind of preparation method of 3- acetylpyridine 浙江理工大学 2019-05-24 CN disclosed