Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | BAX | Q07812 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21010912 | 0.85 | MAPT (0.41) | KEAP1MEN1KMT2AESR1ESR2 | |
| SCHEMBL21010913 | 0.82 | MAPT (0.39) | KEAP1MEN1KMT2AESR1ESR2 | |
| SCHEMBL21010872 | 0.81 | NR4A1 (0.44) | KEAP1MEN1KMT2AESR1ESR2 | |
| SCHEMBL5488305 | 0.80 | ESR1 (0.70) | MEN1KMT2AESR1ESR2LTA4H | |
| SCHEMBL14421265 | 0.80 | ESR1 (0.70) | MEN1KMT2AESR1ESR2LTA4H | |
| SCHEMBL12804905 | 0.80 | ESR1 (0.70) | MEN1KMT2AESR1ESR2LTA4H | |
| SCHEMBL21011167 | 0.79 | ESR2 (0.42) | KEAP1MEN1KMT2AESR1ESR2 | |
| SCHEMBL8349574 | 0.79 | ESR1 (0.61) | KEAP1MEN1KMT2AESR1ESR2 | |
| SCHEMBL16592194 | 0.79 | ESR1 (0.61) | KEAP1MEN1KMT2AESR1ESR2 | |
| SCHEMBL10005890 | 0.79 | ESR1 (0.61) | KEAP1MEN1KMT2AESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109809971-A | Poly benzylidene derivative and its pharmaceutical composition and preparation method and its application | 中国科学院昆明植物研究所 | 2019-05-28 | — | — | CN | claimed |
| CN-109809971-B | Poly-benzyl derivative, pharmaceutical composition thereof, preparation method and application thereof | 中国科学院昆明植物研究所 | 2021-12-10 | — | — | CN | disclosed |
| CN-109809971-A | Poly benzylidene derivative and its pharmaceutical composition and preparation method and its application | 中国科学院昆明植物研究所 | 2019-05-28 | — | — | CN | disclosed |