Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191941 | 1.00 | USP2 (0.44) | USP2SMN1; SMN2GPR119NR1H2HSD17B10 | |
| SCHEMBL4353389 | 1.00 | USP2 (0.44) | USP2SMN1; SMN2GPR119NR1H2HSD17B10 | |
| SCHEMBL1536052 | 0.98 | USP2 (0.42) | USP2SMN1; SMN2GPR119NR1H2HSD17B10 | |
| SCHEMBL3564440 | 0.86 | USP2 (0.42) | USP2SMN1; SMN2GPR119NR1H2MMP1 | |
| SCHEMBL12524861 | 0.86 | USP2 (0.42) | USP2SMN1; SMN2GPR119NR1H2MMP1 | |
| Lithium Ion SCHEMBL1536049 | 0.84 | MMP1 (0.42) | USP2SMN1; SMN2GPR119NR1H2USP30 | |
| SCHEMBL30289256 | 0.84 | MMP1 (0.45) | USP2SMN1; SMN2NR1H2MMP1MMP3 | |
| SCHEMBL1536817 | 0.84 | MMP1 (0.45) | USP2SMN1; SMN2NR1H2MMP1MMP3 | |
| SCHEMBL1536816 | 0.84 | MMP1 (0.45) | USP2SMN1; SMN2NR1H2MMP1MMP3 | |
| SCHEMBL22227 | 0.84 | HSD17B10 (0.51) | USP2SMN1; SMN2GPR119NR1H2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109803963-B | Cyano-substituted heterocycles having USP30 inhibitor activity | 特殊治疗有限公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-109803963-A | The heterocycle that cyano with USP30 inhibitor activity replaces | 特殊治疗有限公司 | 2019-05-24 | — | — | CN | disclosed |