Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536817 | 1.00 | MMP1 (0.45) | MMP1MMP9MMP3MMP7ALDH1A1 | |
| SCHEMBL1536816 | 1.00 | MMP1 (0.45) | MMP1MMP9MMP3MMP7ALDH1A1 | |
| SCHEMBL19339618 | 0.86 | PDE4B (0.43) | MMP1MMP9MMP3MMP7ALDH1A1 | |
| SCHEMBL1849268 | 0.85 | NR1H2 (0.54) | MMP1MMP9MMP3MMP7ALDH1A1 | |
| SCHEMBL282661 | 0.85 | NR1H2 (0.54) | MMP1MMP9MMP3MMP7ALDH1A1 | |
| SCHEMBL919744 | 0.85 | NR1H2 (0.54) | MMP1MMP9MMP3MMP7ALDH1A1 | |
| SCHEMBL191941 | 0.84 | USP2 (0.44) | MMP1MMP9MMP3MMP7ALDH1A1 | |
| SCHEMBL4353389 | 0.84 | USP2 (0.44) | MMP1MMP9MMP3MMP7ALDH1A1 | |
| SCHEMBL28303686 | 0.84 | USP2 (0.44) | MMP1MMP9MMP3MMP7ALDH1A1 | |
| SCHEMBL27619275 | 0.84 | ALDH1A1 (0.41) | MMP1MMP9MMP3MMP7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |