SCHEMBL28305751

SCHEMBL28305751

N#CC(Nc1ccc(Br)cc1)c1ccc(Br)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.61
GAA P10253 1/20 0.61
KDM4E B2RXH2 2/20 0.54
KMT2A Q03164 1/20 0.41
CTSK P43235 1/20 0.40
MMP2 P08253 2/20 0.40
MMP9 P14780 2/20 0.40
MMP8 P22894 2/20 0.40
MMP14 P50281 2/20 0.40
CA12 O43570 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.37
SGMS2 Q8NHU3 3/20 0.37
CNR1 P21554 1/20 0.37
HPGD P15428 1/20 0.36
LMNA P02545 2/20 0.35
MAPT P10636 1/20 0.35
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34
IDO1 P14902 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28305748 0.91 ALDH1A1 (0.53) ALDH1A1GAAKDM4EKMT2ACTSK
SCHEMBL2521895 0.91 ALDH1A1 (0.53) ALDH1A1GAAKDM4EKMT2ACTSK
SCHEMBL11565259 0.91 ALDH1A1 (0.55) ALDH1A1GAAKDM4EKMT2ACTSK
SCHEMBL28305744 0.91 ALDH1A1 (0.64) ALDH1A1GAAKDM4EKMT2ACTSK
SCHEMBL240963 0.87 ALDH1A1 (0.53) ALDH1A1GAAKDM4EKMT2ACTSK
SCHEMBL30731691 0.87 ALDH1A1 (0.85) ALDH1A1GAAKDM4EKMT2ASMN1; SMN2
SCHEMBL30731679 0.76 ALDH1A1 (1.00) ALDH1A1GAAKDM4EKMT2ASMN1; SMN2
SCHEMBL17076429 0.75 ALDH1A1 (0.69) ALDH1A1GAAKDM4EKMT2ASMN1; SMN2
SCHEMBL8971940 0.75 ALDH1A1 (0.69) ALDH1A1GAAKDM4EKMT2ASMN1; SMN2
SCHEMBL19707217 0.73 MMP2 (0.41) ALDH1A1GAAKDM4EKMT2AMMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109928893-A A kind of α-Process for the cyanation of N- arylmethyl aniline 重庆大学 2019-06-25 CN disclosed