SCHEMBL28306997

SCHEMBL28306997

N#Cc1cn(CC(=O)c2ccc(F)cc2)cn1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.43
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42
ALPL P05186 4/20 0.42
PLAA Q9Y263 2/20 0.42
HTT P42858 3/20 0.41
ALPG P10696 2/20 0.41
ALDH1A1 P00352 2/20 0.41
KDM4E B2RXH2 1/20 0.41
TSHR P16473 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
RAB9A P51151 3/20 0.41
NPC1 O15118 2/20 0.41
CYP19A1 P11511 1/20 0.40
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
PTPN1 P18031 1/20 0.39
GRIN2B Q13224 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20491004 0.76 CYP3A4 (0.45) L3MBTL1CA12CA1CA2CA9
SCHEMBL4298196 0.76 ALDH1A1 (0.39) ALDH1A1
SCHEMBL20027458 0.69 GRIN2B (0.43) L3MBTL1HTTALDH1A1KDM4ETSHR
SCHEMBL9795232 0.69 POLB (0.48) L3MBTL1ALPLPLAAALPGSMN1; SMN2
SCHEMBL7241260 0.69 CYP19A1 (0.72) L3MBTL1PLAAALPGCYP19A1CYP11B1
SCHEMBL23118113 0.68 ALDH1A1 (0.37) ALDH1A1
SCHEMBL20702575 0.68 ALDH1A1 (0.37) ALDH1A1
SCHEMBL23118112 0.68 ALDH1A1 (0.37) ALDH1A1
Hydrochloric Acid SCHEMBL9996091 0.68 CYP19A1 (0.70) L3MBTL1PLAAALPGCYP19A1CYP11B1
SCHEMBL24014113 0.66 PANK3 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109982999-A The imidazolyl methyl-derivatives that new 5- replaces 拜耳作物科学股份公司 2019-07-05 CN disclosed