Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30198749 | 0.83 | PPARG (0.42) | HSD11B1MRGPRX4ADRA2AADRA2BADRA2C | |
| SCHEMBL1070284 | 0.83 | PPARG (0.42) | HSD11B1MRGPRX4ADRA2AADRA2BADRA2C | |
| SCHEMBL28978849 | 0.81 | PPARG (0.41) | HSD11B1MRGPRX4ADRA2AADRA2BADRA2C | |
| SCHEMBL28991513 | 0.80 | MRGPRX4 (0.36) | HSD11B1MRGPRX4MEN1KMT2APPARG | |
| SCHEMBL6291525 | 0.80 | MRGPRX4 (0.36) | HSD11B1MRGPRX4ADRA2AADRA2BADRA2C | |
| SCHEMBL29515498 | 0.80 | MRGPRX4 (0.36) | HSD11B1MRGPRX4ADRA2AADRA2BADRA2C | |
| SCHEMBL28941521 | 0.80 | SCN8A (0.41) | TAS2R14HSD11B1MEN1KMT2ASCN8A | |
| SCHEMBL30527011 | 0.80 | IDO1 (0.36) | HSD11B1MRGPRX4PPARGRXRARXRB | |
| SCHEMBL7591797 | 0.80 | IDO1 (0.36) | HSD11B1MRGPRX4PPARGRXRARXRB | |
| SCHEMBL7593287 | 0.79 | MRGPRX4 (0.35) | HSD11B1MRGPRX4ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110062761-A | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and their use as GLUN2B receptor modulators | 詹森药业有限公司 | 2019-07-26 | — | — | CN | disclosed |