Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827578 | 0.88 | GRM5 (0.50) | GRM5RAB9ANPC1KDM4EGAA | |
| SCHEMBL2828434 | 0.87 | MAPT (0.50) | RAB9ANPC1KDM4EGAAMAPT | |
| SCHEMBL2829064 | 0.87 | GRM5 (0.41) | GRM5CYP3A4DRD3SLC6A3RAB9A | |
| SCHEMBL2826802 | 0.87 | RAB9A (0.43) | GRM5CYP3A4RAB9ANPC1KDM4E | |
| SCHEMBL2829032 | 0.85 | NPC1 (0.41) | GRM5CYP3A4DRD3SLC6A3RAB9A | |
| SCHEMBL2826277 | 0.84 | NPC1 (0.40) | GRM5CYP3A4DRD3SLC6A3RAB9A | |
| SCHEMBL2829129 | 0.84 | GRM5 (0.41) | GRM5CYP3A4DRD3SLC6A3RAB9A | |
| SCHEMBL17685477 | 0.83 | NPC1 (0.49) | GRM5CYP3A4DRD3SLC6A3RAB9A | |
| SCHEMBL2826292 | 0.83 | GRM5 (0.44) | GRM5 | |
| SCHEMBL2826577 | 0.83 | RAB9A (0.37) | RAB9ANPC1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |