Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | GCK | P35557 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829064 | 0.90 | GRM5 (0.41) | GRM5CYP3A4DRD3SLC6A3RAB9A | |
| SCHEMBL2832249 | 0.86 | MAPT (0.37) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL2828411 | 0.86 | ADORA1 (0.43) | GRM5RAB9ANPC1GCKMAPT | |
| SCHEMBL2825830 | 0.85 | RAB9A (0.44) | GRM5CYP3A4DRD3SLC6A3RAB9A | |
| SCHEMBL2830060 | 0.84 | ALDH1A1 (0.38) | GRM5RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2830798 | 0.84 | GRM5 (0.44) | GRM5CYP3A4DRD3SLC6A3RAB9A | |
| SCHEMBL2828434 | 0.84 | MAPT (0.50) | RAB9ANPC1MAPTSMARCA2SMARCA4 | |
| SCHEMBL2828219 | 0.83 | SMARCA2 (0.49) | GRM5RAB9ANPC1GCKMAPT | |
| SCHEMBL2831317 | 0.83 | ALDH1A1 (0.34) | GRM5MEN1KMT2A | |
| SCHEMBL2828127 | 0.83 | SMARCA2 (0.42) | GRM5RAB9ANPC1GCKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |