Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.90 |
| ▸ | ESRRG | P62508 | 2/20 | 0.76 |
| ▸ | ESR1 | P03372 | 1/20 | 0.76 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.76 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.67 |
| ▸ | ECE1 | P42892 | 1/20 | 0.67 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.67 |
| ▸ | IKBKB | O14920 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | GCGR | P47871 | 1/20 | 0.60 |
| ▸ | RRM1 | P23921 | 1/20 | 0.58 |
| ▸ | MGAM | O43451 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SI | P14410 | 1/20 | 0.58 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.56 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13475421 | 1.00 | DNM1 (0.90) | DNM1ESRRGESR1ESR2ECE2 | |
| SCHEMBL2830968 | 1.00 | DNM1 (0.90) | DNM1ESRRGESR1ESR2ECE2 | |
| SCHEMBL13569020 | 0.89 | ESR1 (0.89) | DNM1ESRRGESR1ESR2ECE2 | |
| SCHEMBL23327645 | 0.88 | ESR1 (0.74) | DNM1ESRRGESR1ESR2ECE2 | |
| SCHEMBL21211524 | 0.88 | ESR1 (0.74) | DNM1ESRRGESR1ESR2ECE2 | |
| SCHEMBL12937827 | 0.86 | ESRRG (1.00) | DNM1ESRRGESR1ESR2IKBKB | |
| SCHEMBL13186578 | 0.86 | ESRRG (0.79) | DNM1ESRRGNTRK1GCGRGAA | |
| SCHEMBL2663644 | 0.86 | GCGR (0.74) | DNM1ESRRGESR1ESR2GCGR | |
| SCHEMBL13568983 | 0.85 | ESR1 (0.82) | DNM1ESRRGESR1ESR2IKBKB | |
| SCHEMBL30513741 | 0.85 | ESRRG (0.82) | DNM1ESRRGESR1ESR2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2010-02-04 | — | — | US | disclosed |
| EP-1751553-B1 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | UNIV MUENCHEN L MAXIMILIANS (DE) | 2008-10-08 | — | — | EP | disclosed |
| EP-1751553-A2 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | Ludwig-Maximilians-Universität München (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005116640-A2 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | LUDWIG-MAXIMILIANS- UNIVERSITÄT MÜNCHEN (DE) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | PRNP, MAPT, HTT | DNM1 1319/4885ESRRG 4413/4885ESR1 4699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.