SCHEMBL28310239

SCHEMBL28310239

COc1ccc2[nH]cc(CCNOC=O)c2c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 9/20 0.69
MTNR1A P48039 6/20 0.66
MTNR1B P49286 3/20 0.65
BLM P54132 2/20 0.65
PMP22 Q01453 2/20 0.65
KMT2A Q03164 2/20 0.65
CYP1A2 P05177 2/20 0.65
HTR1A P08908 2/20 0.65
CYP2D6 P10635 2/20 0.65
KDM4E B2RXH2 1/20 0.65
MEN1 O00255 1/20 0.65
ALDH1A1 P00352 1/20 0.65
CYP1A1 P04798 1/20 0.65
MPO P05164 1/20 0.65
CYP3A4 P08684 1/20 0.65
HPGD P15428 1/20 0.65
NQO2 P16083 1/20 0.65
HTR2B P41595 1/20 0.65
RAB9A P51151 1/20 0.65
CYP1B1 Q16678 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6923232 0.85 HTR2A (0.72) HTR2AMTNR1AMTNR1BBLMPMP22
Hydrochloric Acid SCHEMBL20970909 0.83 HTR2A (0.97) HTR2AMTNR1AMTNR1BBLMPMP22
SCHEMBL24451304 0.82 HTR2A (1.00) HTR2AMTNR1AMTNR1BBLMPMP22
SCHEMBL30183412 0.82 HTR2A (1.00) HTR2AMTNR1AMTNR1BBLMPMP22
SCHEMBL1130014 0.81 HTR2A (1.00) HTR2AMTNR1AMTNR1BBLMPMP22
SCHEMBL25679654 0.81 HTR2A (0.79) HTR2AMTNR1AMTNR1BBLMPMP22
SCHEMBL29633095 0.81 HTR2A (1.00) HTR2AMTNR1AMTNR1BBLMPMP22
SCHEMBL9019785 0.81 HTR2A (0.82) HTR2AMTNR1AMTNR1BBLMPMP22
SCHEMBL7799780 0.81 MTNR1A (0.78) HTR2AMTNR1AMTNR1BBLMPMP22
SCHEMBL15790793 0.80 HTR2A (0.77) HTR2AMTNR1AMTNR1BBLMPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110156817-A Dievodiamine molecule antitumor derivative and its preparation and application 中国人民解放军第二军医大学 2019-08-23 CN disclosed
CN-105418610-B A kind of 10 hydroxyevodiamine anti-tumor compounds and its preparation method and application 中国人民解放军第二军医大学 2017-07-28 CN disclosed