Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.72 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.69 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.67 |
| ▸ | MPO | P05164 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | NQO2 | P16083 | 1/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17949489 | 0.87 | HTR2A (0.58) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 | |
| SCHEMBL13240228 | 0.85 | HTR2A (0.68) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 | |
| SCHEMBL28310239 | 0.85 | HTR2A (0.69) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 | |
| SCHEMBL24451304 | 0.84 | HTR2A (1.00) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 | |
| SCHEMBL30183412 | 0.84 | HTR2A (1.00) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 | |
| SCHEMBL29633095 | 0.83 | HTR2A (1.00) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 | |
| SCHEMBL1130014 | 0.83 | HTR2A (1.00) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 | |
| SCHEMBL25679654 | 0.83 | HTR2A (0.79) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 | |
| SCHEMBL9019785 | 0.83 | HTR2A (0.82) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 | |
| SCHEMBL7799780 | 0.83 | MTNR1A (0.78) | HTR2AMTNR1AMTNR1BKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110156817-B | Anti-tumor derivative of bi-evodiamine molecule and preparation and application thereof | 中国人民解放军第二军医大学 | 2024-02-27 | — | — | CN | disclosed |
| US-20160214934-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2016-07-28 | — | — | US | disclosed |
| US-8912185-B2 | Use of glutaric acid derivatives or the pharmaceutically acceptable salts thereof as anti-arrhythmic agents | Obschestvo S Ogranichennoi Otvetstvennostyu “Pharmenterprises” (RU) | 2014-12-16 | — | — | US | disclosed |
| WO-2004085392-A1 | MELATONIN DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL DYSFUNCTIONS | FAUST PHARMACEUTICALS (FR) | 2004-10-07 | — | — | WO | disclosed |
| WO-2004085395-A1 | MELATONIN DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL DYSFUNCTIONS | FAUST PHARMACEUTICALS (FR) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214934-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2, BCL2L1 | HTR2A 586/4885MTNR1A 748/4885MTNR1B 1115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.