Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.62 |
| ▸ | PKM | P14618 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.49 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28252821 | 0.89 | LMNA (0.67) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL31327395 | 0.88 | ALDH1A1 (0.56) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL29130781 | 0.88 | MAPT (0.66) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL16449995 | 0.81 | LMNA (0.60) | MAPTPKMPOLBSMN1; SMN2KMT2A | |
| SCHEMBL2421954 | 0.81 | MAPT (0.60) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL7169113 | 0.81 | ALDH1A1 (0.50) | MAPTPOLBSMN1; SMN2GAAKMT2A | |
| SCHEMBL30468041 | 0.81 | MAPT (0.70) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL1700307 | 0.81 | MAPT (0.70) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL3841711 | 0.80 | LMNA (0.55) | MAPTPKMKMT2AALDH1A1TDP1 | |
| SCHEMBL22278705 | 0.80 | LMNA (0.55) | MAPTPKMKMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110054625-A | The bis- target spot inhibitor of N- acyl group benzsulfamide hydroxamic acid Bcl-2, HDAC and preparation method and application | 山东大学 | 2019-07-26 | — | — | CN | claimed |
| CN-110054625-B | N-acylbenzenesulfonamide hydroxamic acid Bcl-2 and HDAC double-target inhibitor, and preparation method and application thereof | 山东大学 | 2022-01-07 | — | — | CN | disclosed |
| CN-110054625-A | The bis- target spot inhibitor of N- acyl group benzsulfamide hydroxamic acid Bcl-2, HDAC and preparation method and application | 山东大学 | 2019-07-26 | — | — | CN | disclosed |