Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Sulfluramid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 16/20 | 0.54 |
| ▸ | CA1 | P00915 | 15/20 | 0.54 |
| ▸ | MMP1 | P03956 | 6/20 | 0.54 |
| ▸ | MMP2 | P08253 | 6/20 | 0.54 |
| ▸ | MMP9 | P14780 | 6/20 | 0.54 |
| ▸ | MMP8 | P22894 | 6/20 | 0.54 |
| ▸ | MMP13 | P45452 | 6/20 | 0.54 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfluramid SCHEMBL26873 | 0.91 | CA2 (0.55) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL9068883 | 0.91 | CA2 (0.55) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL9069077 | 0.91 | CA2 (0.55) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL9068574 | 0.91 | CA2 (0.55) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL9069079 | 0.91 | CA2 (0.55) | CA2CA1MMP1MMP2MMP9 | |
| Sulfluramid SCHEMBL10788641 | 0.91 | CA2 (0.49) | CA2CA1MMP1MMP2MMP9 | |
| Sulfluramid SCHEMBL9101246 | 0.89 | CA2 (0.55) | CA2CA1MMP1MMP2MMP9 | |
| Sulfluramid SCHEMBL2316089 | 0.89 | CA2 (0.53) | CA2CA1MMP1MMP2MMP9 | |
| Sulfluramid SCHEMBL28666475 | 0.89 | CA2 (0.53) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL8105128 | 0.89 | CA2 (0.55) | CA2CA1MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049798-A1 | SYSTEMS, METHODS, AND DEVICES FOR DESTRUCTION OF PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS) AND FOR REACTIVATING SPENT ACTIVATED CARBON | 6K INC. (US) | 2025-03-06 | — | — | WO | claimed |
| CN-113993821-A | Process for removing PFAS from water | 克罗马福拉公司 | 2022-01-28 | — | — | CN | claimed |
| CN-110133154-A | The measuring method of perfluorochemical precursor substance in Atmospheric particulates sampling membrane | 中山大学 | 2019-08-16 | — | — | CN | claimed |
| WO-2025049798-A1 | SYSTEMS, METHODS, AND DEVICES FOR DESTRUCTION OF PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS) AND FOR REACTIVATING SPENT ACTIVATED CARBON | 6K INC. (US) | 2025-03-06 | — | — | WO | disclosed |
| CN-116840388-A | Method for detecting perfluoro and polyfluoroalkyl substances in follicular fluid | 上海交通大学医学院附属新华医院 | 2023-10-03 | — | — | CN | disclosed |
| CN-116359382-A | Placenta transport efficiency assessment method and prediction model | 安徽医科大学第二附属医院 | 2023-06-30 | — | — | CN | disclosed |
| CN-113993821-A | Process for removing PFAS from water | 克罗马福拉公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-110133154-A | The measuring method of perfluorochemical precursor substance in Atmospheric particulates sampling membrane | 中山大学 | 2019-08-16 | — | — | CN | disclosed |