Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.36 |
| ▸ | CCNK | O75909 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30456841 | 0.74 | CCNT1 (0.59) | CCNT1CCNKCDK9CDK12CCNE1 | |
| SCHEMBL24900464 | 0.73 | CCNT1 (0.48) | CCNT1CCNKCDK9CDK12CCNE1 | |
| SCHEMBL30957488 | 0.73 | CCNT1 (0.48) | CCNT1CCNKCDK9CDK12CCNE1 | |
| SCHEMBL30221492 | 0.73 | CCNT1 (0.57) | CCNT1CCNKCDK9CDK12CCNE1 | |
| SCHEMBL17696390 | 0.73 | CCNT1 (0.57) | CCNT1CCNKCDK9CDK12CCNE1 | |
| SCHEMBL29492558 | 0.73 | CCNT1 (0.57) | CCNT1CCNKCDK9CDK12CCNE1 | |
| SCHEMBL517413 | 0.71 | CDK7 (0.54) | CCNT1CCNKCDK9CDK12CCNE1 | |
| SCHEMBL29993829 | 0.71 | CDK7 (0.54) | CCNT1CCNKCDK9CDK12CCNE1 | |
| SCHEMBL28313446 | 0.71 | PDE3B (0.42) | AHRCDK1KDRULK1 | |
| SCHEMBL30957453 | 0.71 | CHRM5 (0.46) | CCNT1CCNKCDK9CDK12CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036004-A | Inhibitors of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2019-07-19 | — | — | CN | disclosed |