Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3447394 | 0.80 | ALDH1A1 (0.59) | KEAP1NFE2L2LMNANAPRTMAPT | |
| SCHEMBL2125283 | 0.79 | KMT2A (0.50) | KEAP1LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL16831885 | 0.77 | SMN1; SMN2 (0.61) | KEAP1NFE2L2LMNANAPRTMAPT | |
| SCHEMBL6390027 | 0.76 | HIF1A (0.50) | KEAP1NFE2L2LMNANAPRTMAPT | |
| SCHEMBL30338836 | 0.75 | NAPRT (0.57) | KEAP1NFE2L2NAPRTMAPTALDH1A1 | |
| SCHEMBL2227366 | 0.75 | NAPRT (0.57) | KEAP1NFE2L2NAPRTMAPTALDH1A1 | |
| SCHEMBL2371844 | 0.75 | NAPRT (0.57) | KEAP1NFE2L2NAPRTMAPTALDH1A1 | |
| SCHEMBL21960091 | 0.75 | NAPRT (0.57) | KEAP1NFE2L2LMNANAPRTMAPT | |
| SCHEMBL18308968 | 0.75 | TSHR (0.57) | NAPRTMAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL28632022 | 0.75 | NAPRT (0.52) | KEAP1NFE2L2LMNANAPRTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110167946-A | Sulfonamide compounds with TNAP inhibitory activity | 第一三共株式会社 | 2019-08-23 | — | — | CN | disclosed |