Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL911440 | 0.77 | HPGD (0.40) | POLBTDP1NNMTHTTALDH1A1 | |
| SCHEMBL29091456 | 0.77 | POLB (0.42) | POLBTDP1NNMTALDH1A1NPC1 | |
| SCHEMBL28935930 | 0.77 | POLB (0.42) | POLBTDP1NNMTALDH1A1NPC1 | |
| SCHEMBL29581181 | 0.77 | HPGD (0.40) | POLBTDP1NNMTHTTALDH1A1 | |
| SCHEMBL7321008 | 0.76 | CYP1A2 (0.44) | POLBTDP1NNMTHTTALDH1A1 | |
| SCHEMBL586103 | 0.76 | NNMT (0.53) | POLBTDP1NNMTHTTALDH1A1 | |
| SCHEMBL323351 | 0.76 | POLB (0.55) | POLBTDP1NNMTHTTALDH1A1 | |
| SCHEMBL2725012 | 0.75 | POLB (0.38) | POLBTDP1NNMTHTTALDH1A1 | |
| SCHEMBL29952969 | 0.75 | POLB (0.38) | POLBTDP1NNMTHTTALDH1A1 | |
| SCHEMBL357954 | 0.74 | NNMT (0.39) | POLBTDP1NNMTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-A | Pyrazolo [1,5-A] pyridine compounds being substituted are as RET kinase inhibitor | 阿雷生物药品公司 | 2019-08-27 | — | — | CN | disclosed |