Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA7 | P43166 | 4/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | IAPP | P10997 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Resorcinol SCHEMBL28105287 | 0.85 | ALDH1A1 (0.57) | TDP1CYP3A4CA12CA1CA2 | |
| SCHEMBL8936329 | 0.83 | HSP90AB1 (0.55) | TDP1CYP3A4MEN1KMT2APTGS1 | |
| Phloroglucinol SCHEMBL28617918 | 0.82 | ALDH1A1 (0.59) | TDP1CYP3A4MEN1KMT2APTGS1 | |
| Hydroquinone SCHEMBL28200844 | 0.82 | TDP1 (0.59) | TDP1CYP3A4MEN1KMT2APTGS1 | |
| SCHEMBL1887087 | 0.77 | — | — | |
| SCHEMBL2357325 | 0.77 | TDP1 (1.00) | TDP1MEN1KMT2ALMNA | |
| SCHEMBL42679 | 0.77 | — | — | |
| SCHEMBL27742164 | 0.77 | TDP1 (0.59) | TDP1CYP3A4MEN1KMT2APTGS1 | |
| SCHEMBL2979251 | 0.76 | MEN1 (0.58) | CYP3A4MEN1KMT2APTGS1DRD3 | |
| SCHEMBL31362118 | 0.76 | CYP3A4 (0.52) | TDP1CYP3A4MEN1KMT2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110183406-A | A kind of preparation method and application of trigrain wheat flavones | 常州大学 | 2019-08-30 | — | — | CN | disclosed |