SCHEMBL2831664

SCHEMBL2831664

COc1ccc(-c2c(O)c(=O)c2=O)c(C)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SHMT2 P34897 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA4 P22748 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
ELANE P08246 1/20 0.43
CYP1A2 P05177 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
HDAC4 P56524 3/20 0.41
HDAC2 Q92769 3/20 0.41
HDAC8 Q9BY41 3/20 0.41
LCK P06239 1/20 0.40
PRKACA P17612 1/20 0.40
PRKACG P22612 1/20 0.40
PRKACB P22694 1/20 0.40
HTT P42858 2/20 0.40
KDM4E B2RXH2 2/20 0.40
ALOX5 P09917 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12326180 0.75 CA1 (0.50) CA1CA2CA4CA7CA9
SCHEMBL8480550 0.74 KDM4E (0.43) CA1CA2CA4CA7CA9
SCHEMBL10667441 0.73 ALDH1A1 (0.41) ELANEKDM4EMEN1KMT2AMAPT
SCHEMBL17178327 0.73 NPC1 (0.44) NPC1
SCHEMBL3671202 0.73 HDAC4 (0.56) CA1CA2CA7CA9HDAC4
SCHEMBL17178230 0.73 CYP1A2 (0.48) CA1CA2CA7CA9CYP1A2
SCHEMBL30532385 0.72 MEN1 (0.43) CA1CA2CA4CA7CA9
SCHEMBL22343599 0.71 ELANE (0.47) CA1CA2CA7CA9ELANE
SCHEMBL17178251 0.70 CYP11B1 (0.50) CA1CA2CA4CA7CA9
SCHEMBL29083061 0.70 ESR2 (0.59) CYP1A2CYP2C9CYP2C19KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8192898-B2 Composition for fluorine-containing volume holographic data recording material and fluorine-containing volume holographic data recording media made of same DAIKIN INDUSTRIES, LTD. (JP) 2012-06-05 US disclosed
US-20100112460-A1 COMPOSITION FOR FLUORINE-CONTAINING VOLUME HOLOGRAPHIC DATA RECORDING MATERIAL AND FLUORINE-CONTAINING VOLUME HOLOGRAPHIC DATA RECORDING MEDIA MADE OF SAME UMEDA CENTER BUILDING (JP) 2010-05-06 US disclosed