Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28041046 | 0.86 | LMNA (0.35) | LMNAGABRA1GABRB2POLBHTT | |
| SCHEMBL17494470 | 0.84 | LMNA (0.34) | LMNAPRKDC | |
| SCHEMBL28320399 | 0.82 | POLB (0.31) | POLBHTTALDH1A1 | |
| SCHEMBL29153429 | 0.80 | LMNA (0.40) | LMNAPOLBPRKDCALDH1A3ALDH1A1 | |
| SCHEMBL28441711 | 0.80 | ALDH1A1 (0.33) | POLBHTTALDH1A1 | |
| SCHEMBL29038305 | 0.75 | KDM5A (0.34) | POLBHTTALDH1A1 | |
| SCHEMBL29038315 | 0.75 | AR (0.30) | — | |
| SCHEMBL16556091 | 0.73 | HTT (0.38) | GABRA1GABRB2POLBHTTALDH1A1 | |
| SCHEMBL8914606 | 0.73 | ALDH1A1 (0.37) | POLBHTTALDH1A1 | |
| SCHEMBL28320395 | 0.73 | TDP1 (0.34) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110143918-B | 3, 4-dihydro-3- (2-hydroxybenzoyl) -2(1H) -quinolinone active skeleton, synthetic method and application | 青岛农业大学 | 2020-08-04 | — | — | CN | disclosed |
| CN-110143918-A | - 2 (1H)-quinolinone activity skeleton of 3,4- dihydro -3- (2- (2-hydroxybenzoyl)) and synthetic method and application | 青岛农业大学 | 2019-08-20 | — | — | CN | disclosed |