Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 10/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.49 |
| ▸ | USP2 | O75604 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31042791 | 1.00 | KDM4C (0.60) | KDM4CCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL16343541 | 0.90 | KDM4C (0.64) | KDM4CCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL22303187 | 0.87 | MAPT (0.65) | KDM4CCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL16343595 | 0.83 | MAPT (0.56) | KDM4CCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL23925667 | 0.81 | CYP1A2 (0.60) | KDM4CCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL31275112 | 0.81 | KDM4C (0.57) | KDM4CCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL30500643 | 0.78 | KDM4C (0.50) | KDM4CCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL28091678 | 0.78 | CYP1A2 (0.58) | KDM4CCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL31719496 | 0.77 | KDM4C (0.62) | KDM4CCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL30711679 | 0.76 | CYP1A2 (0.67) | CYP1A2CYP3A4CYP2D6CLK4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110256432-A | Inhibit the polycyclic compound of MNK1 and MNK2 | 诺沃斯达药业有限公司 | 2019-09-20 | — | — | CN | disclosed |