Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.46 |
| ▸ | TSHR | P16473 | 8/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.46 |
| ▸ | USP2 | O75604 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28320773 | 0.78 | KDM4C (0.60) | KDM4CDHFRCYP1A2CYP3A4TSHR | |
| SCHEMBL31042791 | 0.78 | KDM4C (0.60) | KDM4CDHFRCYP1A2CYP3A4TSHR | |
| SCHEMBL16992915 | 0.76 | KDM4C (0.54) | KDM4CCYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL17149372 | 0.75 | KDM4C (0.53) | KDM4CDHFRCYP1A2CYP3A4TSHR | |
| SCHEMBL28890431 | 0.73 | MEN1 (0.59) | KDM4CCYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL22303187 | 0.73 | MAPT (0.65) | KDM4CCYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL31118682 | 0.73 | CYP1A2 (0.53) | KDM4CCYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL31457009 | 0.72 | KDM4C (0.53) | KDM4CDHFRCYP1A2CYP3A4TSHR | |
| SCHEMBL27376118 | 0.72 | KDM4C (0.53) | KDM4CDHFRCYP1A2CYP3A4TSHR | |
| SCHEMBL23925667 | 0.72 | CYP1A2 (0.60) | KDM4CCYP1A2CYP3A4TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113330014-B | Polycyclic compounds that inhibit MNK1 and MNK2 | 诺沃斯达药业(上海)有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-116425750-A | Salt and crystal of MNK inhibitor compound and preparation method thereof | 诺沃斯达药业(上海)有限公司 | 2023-07-14 | — | — | CN | disclosed |