Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of 1-Methylimidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 2/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Methylimidazole SCHEMBL893393 | 0.98 | QPCT (0.68) | QPCTNFKB1HSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL29133572 | 0.90 | NFKB1 (0.58) | QPCTNFKB1HSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL28572517 | 0.90 | NFKB1 (0.58) | QPCTNFKB1HSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL29133570 | 0.88 | NFKB1 (0.56) | QPCTNFKB1HSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL29242961 | 0.87 | NFKB1 (0.54) | QPCTNFKB1HSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL28357920 | 0.84 | NFKB1 (0.68) | QPCTNFKB1HSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL28730105 | 0.84 | QPCT (0.75) | QPCTNFKB1HSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL26646465 | 0.84 | QPCT (0.75) | QPCTNFKB1HSD17B10QPCTLALDH1A1 | |
| 1-Methylimidazole SCHEMBL27704930 | 0.84 | — | — | |
| 1-Methylimidazole SCHEMBL9198896 | 0.83 | NFKB1 (0.94) | QPCTNFKB1HSD17B10QPCTLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112659299-B | High-water-resistance transport packaging box modified wood based on nanotechnology | 苏州闻洲包装工业有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-112659299-B | High-water-resistance transport packaging box modified wood based on nanotechnology | 苏州闻洲包装工业有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-112086564-A | Passivating agent and passivation method thereof and method for preparing semiconductor film | 杭州纤纳光电科技有限公司 | 2020-12-15 | — | — | CN | disclosed |
| CN-110372678-A | A kind of synthetic method of high-purity crown ether functionalized ion liquid | 山西大学 | 2019-10-25 | — | — | CN | disclosed |