Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | FRK | P42685 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23451864 | 0.78 | CDK2 (0.53) | KITJAK2NTRK1CDK2CCNT1 | |
| SCHEMBL27555122 | 0.78 | CAMKK2 (0.49) | RPS6KA5KITJAK2NTRK1CDK2 | |
| SCHEMBL25156923 | 0.76 | TDO2 (0.67) | RPS6KA5KITNTRK1DYRK1ADYRK2 | |
| SCHEMBL25193942 | 0.76 | PIM1 (0.47) | RPS6KA5KITNTRK1DYRK1ACLK1 | |
| SCHEMBL30407009 | 0.76 | PIM1 (0.47) | RPS6KA5KITNTRK1DYRK1ACLK1 | |
| SCHEMBL30349188 | 0.76 | TDO2 (0.67) | RPS6KA5KITNTRK1DYRK1ADYRK2 | |
| SCHEMBL858766 | 0.75 | CAMKK2 (0.64) | RPS6KA5KITJAK2CDK2CDK9 | |
| SCHEMBL21903027 | 0.73 | RPS6KA5 (0.57) | RPS6KA5JAK2NTRK1CDK9DYRK1A | |
| SCHEMBL25208745 | 0.73 | KIT (0.55) | RPS6KA5KITJAK2NTRK1CDK2 | |
| SCHEMBL25518635 | 0.73 | DYRK1A (0.45) | RPS6KA5NTRK1TNIKDYRK1AAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110337294-A | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会治疗公司 | 2019-10-15 | — | — | CN | disclosed |