SCHEMBL28329316

SCHEMBL28329316

O=c1[nH]c2c(C(F)(F)F)cccc2c(=O)o1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.54
KDM4E B2RXH2 2/20 0.54
MEN1 O00255 1/20 0.54
ALDH1A1 P00352 1/20 0.54
LMNA P02545 1/20 0.54
POLB P06746 1/20 0.54
HPGD P15428 1/20 0.54
HTT P42858 1/20 0.54
KMT2A Q03164 1/20 0.54
HSD17B10 Q99714 1/20 0.53
KIF11 P52732 1/20 0.51
F2 P00734 1/20 0.47
CFD P00746 1/20 0.47
C1R P00736 1/20 0.46
PIM1 P11309 1/20 0.43
PIM3 Q86V86 1/20 0.43
ELANE P08246 2/20 0.41
AR P10275 2/20 0.40
PARP1 P09874 1/20 0.40
MCL1 Q07820 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2061364 0.77 F2 (0.52) ALDH1A1HTTF2CFDC1R
SCHEMBL21658311 0.77 F2 (0.55) SMN1; SMN2ALDH1A1LMNAPOLBKMT2A
SCHEMBL31083618 0.76 KIF11 (0.74) SMN1; SMN2KDM4EMEN1ALDH1A1LMNA
SCHEMBL14698286 0.74 KDM4E (0.35) SMN1; SMN2KDM4EMEN1ALDH1A1LMNA
SCHEMBL14698509 0.74 KDM4E (0.35) SMN1; SMN2KDM4EMEN1ALDH1A1LMNA
SCHEMBL6739074 0.74 F2 (0.52) KDM4EKMT2AHSD17B10F2CFD
SCHEMBL2060660 0.74 F2 (0.52) KDM4EMEN1ALDH1A1POLBKMT2A
SCHEMBL30211329 0.74 F2 (0.52) KDM4EKMT2AHSD17B10F2CFD
SCHEMBL15211017 0.74 F2 (0.52) KDM4EALDH1A1LMNAHPGDHSD17B10
SCHEMBL28715626 0.74 F2 (0.52) F2CFDC1RELANEMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110325540-A Post-transcriptional chemically modified double-stranded RNA 纳诺索尔公司 2019-10-11 CN disclosed