Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28329410 | 0.92 | SIGMAR1 (0.51) | SIGMAR1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL13799649 | 0.87 | SIGMAR1 (0.65) | SIGMAR1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL13369184 | 0.86 | SIGMAR1 (0.55) | SIGMAR1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL23775760 | 0.82 | SIGMAR1 (0.63) | SIGMAR1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL16769232 | 0.82 | SIGMAR1 (0.60) | SIGMAR1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL1631830 | 0.82 | SIGMAR1 (0.46) | SIGMAR1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9354347 | 0.81 | SIGMAR1 (0.56) | SIGMAR1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL4422293 | 0.81 | SIGMAR1 (0.55) | SIGMAR1MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL1633563 | 0.80 | EPHX1 (0.46) | SIGMAR1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL17742668 | 0.78 | SIGMAR1 (0.58) | SIGMAR1MEN1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106103423-B | Pyrazine compounds | 阿斯利康(瑞典)有限公司 | 2019-12-06 | — | — | CN | disclosed |