Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ILK | Q13418 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 9/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485030 | 0.88 | S1PR1 (0.45) | S1PR1S1PR3RAB9AKDM4EMEN1 | |
| SCHEMBL12342541 | 0.87 | S1PR1 (0.44) | S1PR1S1PR3RAB9AKDM4EMEN1 | |
| SCHEMBL2485080 | 0.85 | ILK (0.45) | S1PR1S1PR3RAB9AKDM4EMEN1 | |
| SCHEMBL2483075 | 0.84 | S1PR1 (0.41) | S1PR1S1PR3RAB9AKDM4EMEN1 | |
| SCHEMBL1254602 | 0.84 | S1PR1 (0.49) | S1PR1S1PR3FAAH | |
| SCHEMBL221965 | 0.83 | TBK1 (0.43) | S1PR1S1PR3FAAH | |
| SCHEMBL14877363 | 0.81 | S1PR1 (0.47) | S1PR1S1PR3RAB9AKDM4EMEN1 | |
| SCHEMBL14877364 | 0.81 | S1PR1 (0.47) | S1PR1S1PR3RAB9AKDM4EMEN1 | |
| SCHEMBL12342540 | 0.78 | KDM4E (0.52) | S1PR1S1PR3RAB9AKDM4EMEN1 | |
| SCHEMBL2482859 | 0.71 | S1PR1 (0.44) | S1PR1S1PR3KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170905-A2 | SIRTUIN MODULATING THIAZOLOPYRIDINE COMPOUNDS | Sirtris Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156869-A2 | SIRTUIN MODULATING THIAZOLOPYRIDINE COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |