Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.31 |
| ▸ | RHEB | Q15382 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20916965 | 0.91 | PDE10A (0.42) | PIN1PDE10AMAPK1 | |
| SCHEMBL20920120 | 0.91 | MAPK1 (0.35) | PIN1KDM4EALDH1A1MAPK1RHEB | |
| SCHEMBL22361080 | 0.87 | PIN1 (0.36) | PIN1KDM4EALDH1A1PDE10ACYP3A4 | |
| SCHEMBL28335817 | 0.84 | PDE10A (0.37) | PIN1KDM4EALDH1A1PDE10AMAPK1 | |
| SCHEMBL22284329 | 0.82 | PDE10A (0.40) | PDE10AMAPK1 | |
| SCHEMBL28335650 | 0.81 | PIN1 (0.40) | PIN1MAPK1HRH4RHEBEGLN1 | |
| SCHEMBL28335719 | 0.81 | DGAT1 (0.39) | PIN1MAPK1EGLN1 | |
| SCHEMBL30554282 | 0.79 | RAF1 (0.41) | KDM4EALDH1A1PDE10AMAPK1 | |
| SCHEMBL20917255 | 0.79 | RAF1 (0.41) | KDM4EALDH1A1PDE10AMAPK1 | |
| SCHEMBL28879533 | 0.78 | PIN1 (0.33) | PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110546150-B | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-110546150-A | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD | 2019-12-06 | — | — | CN | disclosed |