Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.50 |
| ▸ | PDE4A | P27815 | 6/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28333806 | 0.91 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28333853 | 0.89 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL28334312 | 0.87 | PDE4B (0.49) | APOBEC3GPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28634406 | 0.86 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL17204895 | 0.85 | TP53 (0.57) | APOBEC3GPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28033773 | 0.81 | PDE4B (0.55) | APOBEC3GPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28333735 | 0.79 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL28034335 | 0.78 | TSHR (0.64) | APOBEC3GPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28034364 | 0.77 | MAPK1 (0.65) | PDE4BPDE4APDE4CPDE4DTSHR | |
| SCHEMBL28034531 | 0.77 | TP53 (0.63) | ALDH1A1HPGDKDM4ETSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085429-B | Aromatic heterocyclic derivative and application thereof in medicines | 广东东阳光药业有限公司 | 2019-12-10 | — | — | CN | disclosed |