Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 8/20 | 0.51 |
| ▸ | KDM1A | O60341 | 5/20 | 0.43 |
| ▸ | FBP1 | P09467 | 2/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | ILK | Q13418 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2835708 | 0.87 | ENPP1 (0.55) | ENPP1EGFRFBP1ERBB2ERBB4 | |
| Hydrochloric Acid SCHEMBL2836487 | 0.80 | EGFR (0.50) | ENPP1EGFRGAKSRCKDR | |
| SCHEMBL2837532 | 0.78 | ENPP1 (0.88) | ENPP1EGFRKDM1AFBP1GAK | |
| SCHEMBL10316371 | 0.78 | ENPP1 (0.60) | ENPP1EGFRKDM1AGAKPDE3A | |
| SCHEMBL24393305 | 0.74 | ENPP1 (0.72) | ENPP1EGFRGAKPDE3ASRC | |
| SCHEMBL2836489 | 0.74 | ENPP1 (0.56) | ENPP1EGFRKDM1AGAKSRC | |
| SCHEMBL10316186 | 0.73 | ENPP1 (0.55) | ENPP1EGFRKDM1AKDR | |
| SCHEMBL8974040 | 0.71 | ENPP1 (0.49) | ENPP1EGFRPDE3A | |
| SCHEMBL2840274 | 0.68 | ENPP1 (0.49) | ENPP1EGFRKDM1AGAKPDE3A | |
| SCHEMBL1985866 | 0.67 | KDM1A (0.57) | EGFRKDM1AFBP1GAKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101878203-A | Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents | NATCO PHARMA LTD | 2010-11-03 | — | — | CN | claimed |
| US-20100261740-A1 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT | NATCO PHARMA LIMITED (IN) | 2010-10-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261740-A1 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT | MKI67, CDKL5, CCNI | ENPP1 2397/4885EGFR 1110/4885KDM1A 2055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.