Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 12/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2835708 | 0.83 | ENPP1 (0.55) | EGFRENPP1 | |
| Hydrochloric Acid SCHEMBL2833454 | 0.80 | ENPP1 (0.57) | EGFRKDRENPP1GAKSRC | |
| SCHEMBL27816759 | 0.78 | EGFR (0.56) | EGFRKDRENPP1LCKGAK | |
| SCHEMBL1260737 | 0.76 | ENPP1 (0.54) | EGFRKDRENPP1LCKGAK | |
| SCHEMBL1985538 | 0.76 | LCK (0.66) | EGFRKDRENPP1LCKFLT3 | |
| SCHEMBL23726845 | 0.74 | ENPP1 (0.53) | EGFRKDRENPP1LCKGAK | |
| SCHEMBL3166753 | 0.74 | PDE5A (0.57) | EGFRKDRENPP1LCKGAK | |
| SCHEMBL19933282 | 0.74 | ENPP1 (0.53) | EGFRKDRENPP1LCKGAK | |
| SCHEMBL2476964 | 0.74 | RET (0.55) | EGFRKDRENPP1LCKFLT3 | |
| SCHEMBL364049 | 0.74 | ENPP1 (0.81) | EGFRKDRENPP1LCKGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101878203-A | Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents | NATCO PHARMA LTD | 2010-11-03 | — | — | CN | claimed |
| US-20100261740-A1 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT | NATCO PHARMA LIMITED (IN) | 2010-10-14 | — | — | US | claimed |
| CN-101878203-A | Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents | NATCO PHARMA LTD | 2010-11-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261740-A1 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT | MKI67, CDKL5, CCNI | ACHE 3165/4885EGFR 1110/4885KDR 1689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.