Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.38 |
| ▸ | MTOR | P42345 | 4/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22284233 | 0.90 | PIK3CA (0.39) | PDE10AKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL22284231 | 0.86 | MAPK1 (0.43) | KDM4EALDH1A1FAAH | |
| SCHEMBL22284167 | 0.86 | MAPK1 (0.43) | KDM4EALDH1A1FAAH | |
| SCHEMBL28335650 | 0.80 | PIN1 (0.40) | EGLN1 | |
| SCHEMBL16213579 | 0.80 | MAPK1 (0.55) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL22361080 | 0.76 | PIN1 (0.36) | PDE10AKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL22284152 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL28333301 | 0.75 | PIN1 (0.40) | PDE10AKDM4EALDH1A1EGLN1 | |
| SCHEMBL22284171 | 0.73 | CYP1A2 (0.46) | PKMKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL28335817 | 0.73 | PDE10A (0.37) | PDE10AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110546150-B | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-110546150-A | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD | 2019-12-06 | — | — | CN | disclosed |