Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.37 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.37 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.37 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14769887 | 1.00 | GAA (0.43) | GAAABCB1TSHRBCHEPTGES2 | |
| SCHEMBL2505924 | 0.92 | NPC1 (0.40) | GAAABCB1TSHRBCHEPTGES2 | |
| SCHEMBL4261396 | 0.92 | NPC1 (0.40) | GAAABCB1TSHRBCHEPTGES2 | |
| SCHEMBL14769891 | 0.86 | GAA (0.43) | GAAABCB1TSHRBCHEPTGES2 | |
| SCHEMBL28502618 | 0.86 | GAA (0.43) | GAAABCB1TSHRBCHEPTGES2 | |
| SCHEMBL28403240 | 0.85 | GAA (0.42) | GAAABCB1TSHRBCHEPTGES2 | |
| SCHEMBL14769876 | 0.83 | LMNA (0.40) | GAAABCB1TSHRBCHEMAPK1 | |
| SCHEMBL28412125 | 0.83 | ABCB1 (0.44) | GAAABCB1TSHRKMT2ASLC43A1 | |
| SCHEMBL13187913 | 0.81 | ALDH1A1 (0.50) | GAAMAPK1HIF1ALGALS9LGALS1 | |
| SCHEMBL18271833 | 0.81 | ALDH1A1 (0.50) | GAAMAPK1HIF1ALGALS9LGALS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106905398-B | Synthetic method of sofosbuvir | ZHEJIANG A & F UNIVERSITY (CN) | 2019-12-10 | — | — | CN | claimed |
| CN-110669085-A | Preparation method of sofosbuvir intermediate | 上海迪赛诺药业股份有限公司 | 2020-01-10 | — | — | CN | disclosed |
| CN-110669085-A | Preparation method of sofosbuvir intermediate | 上海迪赛诺药业股份有限公司 | 2020-01-10 | — | — | CN | disclosed |
| CN-106905398-B | Synthetic method of sofosbuvir | ZHEJIANG A & F UNIVERSITY (CN) | 2019-12-10 | — | — | CN | disclosed |
| CN-106905398-B | Synthetic method of sofosbuvir | ZHEJIANG A & F UNIVERSITY (CN) | 2019-12-10 | — | — | CN | disclosed |