Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823730 | 0.86 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL2823728 | 0.86 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL2826917 | 0.83 | HSD11B1 (0.55) | HSD11B1 | |
| SCHEMBL2826915 | 0.83 | HSD11B1 (0.55) | HSD11B1 | |
| SCHEMBL2821767 | 0.81 | HSD11B1 (0.57) | HSD11B1 | |
| SCHEMBL2821770 | 0.81 | HSD11B1 (0.57) | HSD11B1 | |
| SCHEMBL2021692 | 0.76 | HSD11B1 (0.64) | EPHX2HSD11B1KMT2ACNR1CNR2 | |
| SCHEMBL2833815 | 0.75 | SIGMAR1 (0.40) | EPHX2HSD11B1KMT2A | |
| SCHEMBL2822252 | 0.74 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL2822251 | 0.74 | HSD11B1 (0.45) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507493-B2 | Amide and amidine derivatives and uses thereof | ABBVIE INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20100267738-A1 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | ABBOTT LABORATORIES (US) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267738-A1 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | HSD11B2, HSD11B1, HSD17B2 | EPHX2 1112/4885HSD11B1 2/4885KMT2A 2829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.