Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL29013076 | 0.89 | KMT2A (0.63) | KDM4EMAPTKMT2AMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28481662 | 0.88 | KDM4E (0.64) | KDM4EMAPTKMT2AMEN1LMNA | |
| Tryptophan SCHEMBL14691207 | 0.86 | KDM4E (0.63) | KDM4EMAPTKMT2AMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28496362 | 0.86 | KMT2A (0.68) | KDM4EMAPTKMT2AMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28831650 | 0.83 | CTSC (0.41) | KDM4EMAPTKMT2AMEN1LMNA | |
| Dl-Tryptophan SCHEMBL16345061 | 0.83 | KDM4E (0.54) | KDM4EMAPTKMT2AMEN1LMNA | |
| Dl-Tryptophan SCHEMBL27169619 | 0.83 | KMT2A (0.54) | KDM4EMAPTKMT2AMEN1LMNA | |
| Tryptophan SCHEMBL7356323 | 0.83 | KDM4E (0.73) | KDM4EMAPTKMT2AMEN1LMNA | |
| Tryptophan SCHEMBL1860250 | 0.83 | KDM4E (0.73) | KDM4EMAPTKMT2AMEN1LMNA | |
| Dl-Tryptophan SCHEMBL7356311 | 0.83 | KDM4E (0.73) | KDM4EMAPTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590915-A | Artificial antibacterial peptide CAH, preparation method and application thereof | 陕西科技大学 | 2019-12-20 | — | — | CN | disclosed |