Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MAGI3 | Q5TCQ9 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRPR | P30550 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL27789301 | 0.89 | CTSC (0.41) | CTSCMEN1KMT2AKDM4EMAPT | |
| Dl-Tryptophan SCHEMBL27169619 | 0.87 | KMT2A (0.54) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL27342636 | 0.85 | CTSC (0.38) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL3624598 | 0.84 | MEN1 (0.42) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL14856211 | 0.84 | KMT2A (0.46) | CTSCMEN1KMT2AKDM4EMAPT | |
| Dl-Tryptophan SCHEMBL28338596 | 0.83 | KDM4E (0.50) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL27677376 | 0.83 | TLR2 (0.37) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL3626370 | 0.83 | MEN1 (0.41) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL27503845 | 0.82 | GHSR (0.39) | GLP1R | |
| Tryptophan SCHEMBL9551469 | 0.81 | KDM4E (0.53) | CTSCMEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105765067-A | Modified beta-galactosidase | 天野酶株式会社 | 2016-07-13 | — | — | CN | claimed |
| CN-105765067-A | Modified beta-galactosidase | 天野酶株式会社 | 2016-07-13 | — | — | CN | disclosed |