SCHEMBL28339595

SCHEMBL28339595

Cn1c(C(=O)Nc2cccc(Br)c2Cl)nc2c1CCN(C(=O)O)C2

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 20/20 0.59
CD274 Q9NZQ7 20/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30010102 1.00 PDCD1 (0.59) PDCD1CD274
SCHEMBL28337336 0.91 PDCD1 (0.52) PDCD1CD274
SCHEMBL28339592 0.89 PDCD1 (0.58) PDCD1CD274
SCHEMBL20293196 0.89 PDCD1 (0.74) PDCD1CD274
SCHEMBL27133653 0.89 PDCD1 (0.51) PDCD1CD274
SCHEMBL27036653 0.89 PDCD1 (0.51) PDCD1CD274
SCHEMBL29812811 0.87 PDCD1 (0.54) PDCD1CD274
SCHEMBL20293591 0.87 PDCD1 (0.54) PDCD1CD274
SCHEMBL28963545 0.85 PDCD1 (0.52) PDCD1CD274
SCHEMBL20314451 0.85 PDCD1 (0.58) PDCD1CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112752756-B Tetrahydro-imidazo [4,5-c ] pyridine derivatives as PD-L1 immunomodulators 因赛特公司 2024-06-25 CN disclosed
CN-110582493-B Benzoxazole derivatives as immunomodulators 因赛特公司 2024-03-08 CN disclosed
CN-113348170-B Biphenyl derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2023-12-22 CN disclosed
CN-116115764-A Tetrahydroimidazo [4,5-C ] pyridine derivatives as PD-L1 internalization inducers 因赛特公司 2023-05-16 CN disclosed
CN-113348170-A Biphenyl derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2021-09-03 CN disclosed
CN-113072551-A Nitrogen-containing biphenyl derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2021-07-06 CN disclosed
CN-110582493-A Benzoxazole derivatives as immunomodulators 因赛特公司 2019-12-17 CN disclosed