SCHEMBL28340282

SCHEMBL28340282

CC(C)(C)OC(=O)N[C@@H](Cc1ccc(Br)cc1F)C(=O)OC(C)(C)C

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 7/20 0.52
CTSS P25774 6/20 0.50
CTSK P43235 6/20 0.50
CTSB P07858 1/20 0.46
ALDH1A1 P00352 1/20 0.44
MAPT P10636 1/20 0.44
TACR1 P25103 1/20 0.42
PTPN1 P18031 1/20 0.42
CACNA1B Q00975 1/20 0.41
SCN9A Q15858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18170221 1.00 AAK1 (0.52) AAK1CTSSCTSKCTSBALDH1A1
SCHEMBL19858730 0.94 AAK1 (0.51) AAK1CTSSCTSKCTSBALDH1A1
SCHEMBL17483620 0.94 AAK1 (0.51) AAK1CTSSCTSKCTSBALDH1A1
SCHEMBL27124976 0.92 ALDH1A1 (0.54) AAK1CTSSCTSKCTSBALDH1A1
SCHEMBL16447830 0.91 CTSS (0.53) AAK1CTSSCTSKCTSBPTPN1
SCHEMBL16064072 0.91 CTSS (0.53) AAK1CTSSCTSKCTSBPTPN1
SCHEMBL16035979 0.89 AAK1 (0.51) AAK1CTSSCTSKCTSBALDH1A1
SCHEMBL30476240 0.89 AAK1 (0.51) AAK1CTSSCTSKCTSBALDH1A1
SCHEMBL19858738 0.89 AAK1 (0.51) AAK1CTSSCTSKCTSBALDH1A1
SCHEMBL21722664 0.88 CTSS (0.52) AAK1CTSSCTSKCTSBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110642878-A Preparation method of fluorine-labeled BPA 中国医学科学院北京协和医院 2020-01-03 CN disclosed
CN-110642879-A Preparation method of fluorine-labeled BPA 中国医学科学院北京协和医院 2020-01-03 CN disclosed