Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 2/20 | 0.43 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 5/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL4961509 | 0.93 | KMT2A (0.53) | KMT2AKDM4ELMNAMAPTTSHR | |
| Tryptophan SCHEMBL4961514 | 0.93 | KMT2A (0.53) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL28340345 | 0.92 | KMT2A (0.56) | KMT2AKDM4ELMNAMAPTTSHR | |
| Tryptophan SCHEMBL28555110 | 0.89 | IL23R (0.47) | — | |
| Tryptophan SCHEMBL18297981 | 0.87 | KMT2A (0.61) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL29163825 | 0.87 | KMT2A (0.60) | KMT2AKDM4ELMNAMAPTTSHR | |
| Tryptophan SCHEMBL1996751 | 0.87 | KMT2A (0.63) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL1996746 | 0.87 | KMT2A (0.63) | KMT2AKDM4ELMNAMAPTTSHR | |
| Tyrosine SCHEMBL29089914 | 0.87 | SLC7A5 (0.47) | KDM4EHIF1AERAP2LNPEPADORA3 | |
| Tryptophan SCHEMBL11020148 | 0.86 | MEN1 (0.53) | KMT2AKDM4ELMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590927-B | Gecko verrucosa antioxidant peptide and application thereof | 济宁医学院 | 2022-06-14 | — | — | CN | disclosed |
| CN-110590927-A | Gekko verrucosa antioxidant peptide and application thereof | 济宁医学院 | 2019-12-20 | — | — | CN | disclosed |