Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL18297990 | 0.95 | SLC7A5 (0.52) | SLC7A5ITGB3ITGA2BGSRLNPEP | |
| Tyrosine SCHEMBL9978769 | 0.95 | SLC7A5 (0.52) | SLC7A5ITGB3ITGA2BGSRLNPEP | |
| Histidine SCHEMBL28560079 | 0.91 | GSR (0.48) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Histidine SCHEMBL5580739 | 0.91 | GSR (0.48) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL9978767 | 0.89 | SLC7A5 (0.46) | SLC7A5ITGB3ITGA2BGSRLNPEP | |
| Tryptophan SCHEMBL28340346 | 0.87 | KMT2A (0.47) | LNPEPERAP2KDM4EADORA3ALOX15 | |
| Phenylalanine SCHEMBL18297982 | 0.87 | SLC7A5 (0.50) | SLC7A5ITGB3ITGA2BGSRLNPEP | |
| Tyrosine SCHEMBL6429835 | 0.86 | SLC7A5 (0.63) | SLC7A5ITGB3ITGA2BGSRLNPEP | |
| Tyrosine SCHEMBL5666710 | 0.86 | SLC7A5 (0.63) | SLC7A5ITGB3ITGA2BGSRLNPEP | |
| Tyrosine SCHEMBL27692833 | 0.85 | SLC7A5 (0.42) | SLC7A5ITGB3ITGA2BLNPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116726241-B | Collagen hemostatic and antibacterial dressing and preparation method thereof | 江苏亨瑞生物医药科技有限公司 | 2023-10-20 | — | — | CN | claimed |
| CN-116726241-A | Collagen hemostatic and antibacterial dressing and preparation method thereof | 江苏亨瑞生物医药科技有限公司 | 2023-09-12 | — | — | CN | claimed |
| CN-116726241-B | Collagen hemostatic and antibacterial dressing and preparation method thereof | 江苏亨瑞生物医药科技有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-116726241-A | Collagen hemostatic and antibacterial dressing and preparation method thereof | 江苏亨瑞生物医药科技有限公司 | 2023-09-12 | — | — | CN | disclosed |