SCHEMBL28340655

SCHEMBL28340655

C#Cc1ccc(C2OCCO2)c(F)c1

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 2/20 0.31
CYP11B2 P19099 2/20 0.31
CYP17A1 P05093 1/20 0.30
CYP19A1 P11511 1/20 0.30
HRH1 P35367 1/20 0.30
KCNH2 Q12809 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20099757 0.86 CYP11B1 (0.31) CYP11B1CYP11B2
SCHEMBL122002 0.77 CYP11B2 (0.43) CYP11B1CYP11B2CYP17A1CYP19A1HRH1
SCHEMBL5040961 0.76 HTR2C (0.47)
SCHEMBL11230627 0.74 OPRL1 (0.38) CYP11B1CYP11B2CYP17A1CYP19A1HRH1
SCHEMBL30409263 0.73 KDM1A (0.53)
SCHEMBL509469 0.73 KDM1A (0.53)
SCHEMBL11232055 0.72 OPRL1 (0.40) CYP11B1CYP11B2CYP17A1CYP19A1HRH1
SCHEMBL11235730 0.72 OPRL1 (0.40) CYP11B1CYP11B2CYP17A1CYP19A1HRH1
SCHEMBL3456073 0.71 HTR2C (0.47)
SCHEMBL28326169 0.70 CYP11B1 (0.31) CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110483408-A A kind of N- methyl substituted benzimidazole side fluorine liquid-crystal compounds of big birefringence and preparation method thereof UNIV SHAANXI NORMAL 2019-11-22 CN disclosed