SCHEMBL28341024

SCHEMBL28341024

[CH2]CN1CCN(Cc2ccc(-n3c(O)nnc3-c3cc(C(C)C)c(O)cc3O)cc2)CC1

nearest known ligand 0.47

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 19/20 0.47
HSP90AB1 P08238 11/20 0.47
HSP90B1 P14625 4/20 0.41
TRAP1 Q12931 3/20 0.41
PDK1 Q15118 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17065471 0.92 HSP90AA1 (0.45) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1
SCHEMBL22354461 0.91 HSP90AA1 (0.48) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1
SCHEMBL28343989 0.90 HSP90AA1 (0.44) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1
SCHEMBL30385274 0.90 HSP90AA1 (0.50) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1
SCHEMBL16569718 0.89 HSP90AA1 (0.43) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1
SCHEMBL22541228 0.88 HRH3 (0.46) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1
SCHEMBL20879073 0.88 HSP90AA1 (0.45) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1
SCHEMBL30985941 0.88 HRH3 (0.46) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1
SCHEMBL5002925 0.88 PDK1 (0.52) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1
SCHEMBL15522473 0.88 HSP90AA1 (0.47) HSP90AA1HSP90AB1HSP90B1TRAP1PDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110559446-A Targeted therapeutics 马德里加尔制药公司 2019-12-13 CN disclosed