SCHEMBL28341815

SCHEMBL28341815

Cc1ccc(CCl)nc1C#N.Cc1ccc(CO)nc1C#N

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.36
MBOAT4 Q96T53 2/20 0.31
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2953123 0.92 ALDH1A1 (0.34) MBOAT4ALDH1A1
SCHEMBL929492 0.92 CCR1 (0.42) CCR1MBOAT4ALDH1A1
SCHEMBL928928 0.74 CCR1 (0.42) CCR1MBOAT4ALDH1A1
SCHEMBL25786895 0.74 MEN1 (0.37) MBOAT4ALDH1A1
SCHEMBL16419615 0.74 MBOAT4 (0.42) CCR1MBOAT4ALDH1A1
SCHEMBL17781666 0.72 MBOAT4 (0.43) MBOAT4ALDH1A1
SCHEMBL930960 0.71 KDM4E (0.40) MBOAT4ALDH1A1
SCHEMBL16224716 0.70 CCR1 (0.42) CCR1MBOAT4
SCHEMBL16213203 0.70 MBOAT4 (0.37) MBOAT4ALDH1A1
SCHEMBL16419646 0.70 USP8 (0.43) MBOAT4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106414429-B Pyrazole compounds and their use as T-type calcium channel blockers 爱杜西亚药品有限公司 2020-01-03 CN disclosed